The Mutant Response Division were a group of elite soldiers designed to protect the world from the percieved threat of mutants, as such, they were enemies of the X-Men and part of the much larger mutantphobia pandemic that has always plagued the Marvel Universe. The MRD are also ultimately the unknown pawns of Bastion, who orchestrated the events necessary to prompt the creation of the team - all as part of his master plan to exterminate mutants from existence.
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