USS Leslie L. B. Knox (DE-580) was a Rudderow-class destroyer escort in the United States Navy during World War II. Leslie L. B. Knox was laid down 7 November 1943 by the Bethlehem-Hingham Shipyard, Inc., Hingham, Massachusetts; launched 8 January 1944; sponsored by Louise Kennedy Knox, widow of Lieutenant (jg.) Knox; and commissioned 22 March 1944, Lt. J. A. Moffett in command. Leslie L. B. Knox received three battle stars for World War II service