| abstract | - Dr. Owen (Jonathan Mellor), an official from the Ministry of Health, and a GEO team equipped with helmet-mounted video cameras are sent into a quarantined apartment building to control the situation. After encountering some of the infected, Owen uses religious mantra and rosary to fight them off. It turns out that Owen is actually a priest sent by the Vatican to get a blood sample from a possessed girl named Tristana Medeiros and aid the other priest in charge of her. When they get to the penthouse, they find out that the infected can travel all around the building through the air ducts. Tristana is nowhere to be found. Larra (Ariel Casas), one of the GEO officers, goes into the air duct and finds a sample of her blood – the only one that the original priest took from her. Owen then performs a religious rite, and the blood spontaneously combusts, confirming that it is the blood he's looking for; however, the rest of the blood also sets on fire and Fernandez, commanding officer of the GEO team drops it, rendering it useless. Owen tells them that they must get a blood sample from Tristana herself. Jennifer's father (Pep Molina), who was outside getting medicine for his daughter (the infected Jennifer from the first installment), manages to convince a firefighter to take him into the building. Moments before the building is quarantined, three teenagers named Tito (Pau Poch), Mire (Andrea Ros) and Ori are messing around on a roof. When the police seal off the building, they find them and escort them out to the street. The teenagers gain access to the building through the sewage system; however, police have seen them and seal their exit. Inside, the teenagers find Jennifer's father and the firefighter; they attempt to leave the building through the sewage system only to find it sealed, much to the dismay of the firefighter. After some deaths from attacks by the possessed, the two groups find each other. Tito gets bitten by the infected, and they restrain him and lock Mire and Ori in a room. Then the group finds Ángela Vidal (Manuela Velasco), the reporter from REC, who still has her camera with her. Owen then forces Tito to tell him where Tristana Medeiros is. The demon possessing Tito tells him that she is "in the highest." Owen figures out that this means that she is in the penthouse. The GEO team leader argues that they had already cleared that area and did not see anything. The demon then gives a hint that the "light" blinds them from seeing the path. When Ángela is asked how she saw Tristana, she says she saw her through the camera's night vision. Owen deduces that some things can only be seen in the dark. They go back to the penthouse. When they turn on the camera's night vision, a door appears that leads them to a room. They find a tub filled with water that cannot be seen when the lights are on. While Fernandez investigates it, Tristana leaps out of the water and drags him in. They turn the lights on only to witness that he and Tristana had disappeared. They turn the lights off again and try to remain silent not to alarm Tristana. After Owen's radio starts producing noises, Tristana attacks them and after some struggling, Ángela blows her head off with a shotgun. Owen is enraged because he needed the blood sample, but all Ángela wants to do is leave the building. At this point, the only survivors left are Ángela, Owen, and Rosso (Pablo Rosso), a GEO officer. When Owen refuses to authorize their exit, Ángela starts to beat him to force him to do so. Rosso tells her to stop, but she shoots and kills him. It is then revealed that Tristana has possessed Ángela, so she can leave the darkness she was trapped in, and consequently the building. After telling Owen that she does not need him to get out as she can impersonate his voice, she kills him. She takes his radio and, using Owen's voice, says that the mission is over and that they can let them out. She also tells them that he is staying behind because he is infected and the only survivor is a woman, Ángela. When asked how the woman survived, the demonic Ángela looks at the camera and smiles. The ending of the first film is shown, but extended to reveal how the demon possessed Ángela, who went into hiding as Owen and the GEO team broke into the penthouse earlier in the film.
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