| shortdesc | - Sheldon J. Plankton is ' nemesis and the main antagonist in the series.
- SpongeBob SquarePants is the main protagonist of the animated comedy series of the same name.
- Patrick Star is 's best friend.
- Squidward Tentacles is the neighbor of and .
- Eugene H. Krabs is a sea crab who is the owner of the Krusty Krab.
- Sandra "Sandy" Cheeks is a squirrel and one of 's best friends.
- Gary the Snail is 's loyal pet, although his behavior in several aspects resembles a snail.
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