| rdfs:comment | - Background Re: Is physical frailty inevitable as we grow older? Posted by: "samuel9888" Sam68123@cox.net samuel9888 Fri Nov 18, 2011 8:29 am (PST) Also known as "Kaatsu" training, it involves restricting blood flow proximally to the muscles being worked with a tourniquet or pressurized cuff and using lighter loads. Teresa Merrick, Ph.D. Bellevue --- In Supertraining@yahoogroups.com, Ralph Giarnella wrote: > In comparison, low-intensity blood flow restriction (BFR) exercise stimulates MPS and mTORC1 signaling to an extent similar to traditional, high-intensity resistance exercise.
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| abstract | - Background Re: Is physical frailty inevitable as we grow older? Posted by: "samuel9888" Sam68123@cox.net samuel9888 Fri Nov 18, 2011 8:29 am (PST) Also known as "Kaatsu" training, it involves restricting blood flow proximally to the muscles being worked with a tourniquet or pressurized cuff and using lighter loads. There is quite a bit of research being conducted on the methodology: I saw quite a few poster presentations on it at the American College of Sports Medicine Annual Meeting this year. For published research, you might have to search Google Scholar or Pubmed on the generic term "blood flow restriction exercise". Teresa Merrick, Ph.D. Bellevue --- In Supertraining@yahoogroups.com, Ralph Giarnella wrote: > > The following article might be appropriate to this discussion. > One question: does any one now what is meant by "low-intensity blood flow restriction(BFR) exercise"? > Ralph Giarnella MD > Southington Ct. USA > ********************* > Medicine & Science in Sports & Exercise: > December 2011 - Volume 43 - Issue 12 - p 2249â€"2258 > doi: 10.1249/MSS.0b013e318223b037 > Basic Sciences > Exercise, Amino Acids, and Aging in the Control of Human Muscle Protein Synthesis > WALKER, DILLON K.1,2; DICKINSON, JARED M.1,2; TIMMERMAN, KYLE L.1,2,3; DRUMMOND, MICAH J.1,2,3; REIDY, PAUL T.1,2; FRY, CHRISTOPHER S.1,2; GUNDERMANN, DAVID M.1,2; RASMUSSEN, BLAKE B.1,2,3 > > > Abstract > > ABSTRACT: In this review, we discuss recent research in the field of human skeletal muscle protein metabolism characterizing the acute regulation of mammalian target of rapamycin complex (mTORC) 1 signaling and muscle protein synthesis (MPS) by exercise, amino acid nutrition, and aging. > Resistance exercise performed in the fasted state stimulates mixed MPS within 1 h after exercise, which can remain elevated for 48 h. We demonstrate that the activation of mTORC1 signaling (and subsequently enhanced translation initiation) is required for the contraction-induced increase in MPS. > In comparison, low-intensity blood flow restriction (BFR) exercise stimulates MPS and mTORC1 signaling to an extent similar to traditional, high-intensity resistance exercise. > We also show that mTORC1 signaling is required for the essential amino acid (EAA)â€"induced increase in MPS. > Ingestion of EAAs (or protein) shortly after resistance exercise enhances MPS and mTORC1 signaling compared with resistance exercise or EAAs alone. > In older adults, the ability of the skeletal muscle to respond to anabolic stimuli is impaired. For example, in response to an acute bout of resistance exercise, older adults are less able to activate mTORC1 or increase MPS during the first 24 h of postexercise recovery. > However, BFR exercise can overcome this impairment. Aging is not associated with a reduced response to EAAs provided the EAA content is sufficient. Therefore, we propose that exercise combined with EAA should be effective not only in improving muscle repair and growth in response to training in athletes, but that strategies such as EAA combined with resistance exercise (or BFR exercise) may be very useful as a countermeasure for sarcopenia and other clinical conditions associated with muscle wasting.
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