The Howard Hughes Medical Institute is one of the largest private medical research funding institutes and the second largest philanthropic organization in the United States. It was founded by billionaire Howard Hughes in 1953 in order to comply with a demand by the United States Defence Department that Hughes divest himself of his ownership interest in Hughes Aircraft, a major defense contractor. However, until Hughes' death, it was under consistent review by the IRS which challenged its status as a non-profit. This article is a , please help House Wikia by expanding it.
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