Some sidechains have only one position, but others can be "flipped" to multiple positions. In Foldit, you can click and drag on a sidechain to move it to another position. Shake and wiggle can also help move sidechains to their best position. Other tools can also cause sidechains to move to different positions. Sidechains can be either hydrophobic or hydrophilic. Using its default color options, Foldit shows hydrophobic sidechains in orange and hydrophilic sidechains in blue. It's important for hydrophobic sidechains for be buried in the core of the protein.
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