About: Symmetry puzzle

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An Entity of Type : owl:Thing, within Data Space : 134.155.108.49:8890 associated with source dataset(s)

In a symmetry puzzle, there are multiple copies of the same protein. Players can work on one copy of the protein, called the "monomer" or "main chain", in the usual way. The monomer is colored normally, while the other copies of the protein are normally gray. Changes made to the monomer are automatically reflected in the copies. The design goals for a oligomer are generally similar to those for a monomer. For example, the oligomer complex should be tightly packed, ideally with few voids between the monomer and the copies.

Attributes	Values
rdfs:label	Symmetry puzzle
rdfs:comment	In a symmetry puzzle, there are multiple copies of the same protein. Players can work on one copy of the protein, called the "monomer" or "main chain", in the usual way. The monomer is colored normally, while the other copies of the protein are normally gray. Changes made to the monomer are automatically reflected in the copies. The design goals for a oligomer are generally similar to those for a monomer. For example, the oligomer complex should be tightly packed, ideally with few voids between the monomer and the copies.
dcterms:subject	Puzzle Types Tools dbkwik:resource/SmmkF-eBKeTUOGVLPiS1Bw==
abstract	In a symmetry puzzle, there are multiple copies of the same protein. Players can work on one copy of the protein, called the "monomer" or "main chain", in the usual way. The monomer is colored normally, while the other copies of the protein are normally gray. Changes made to the monomer are automatically reflected in the copies. The first goal of a symmetry puzzle is to produce a well-folded monomer, just as in a standard design puzzle. The next goal is to assemble the monomer and the copies into a "oligomer", or what Foldit usually calls a "complex". The area where the copies connect to each other is called the "interface". The design goals for a oligomer are generally similar to those for a monomer. For example, the oligomer complex should be tightly packed, ideally with few voids between the monomer and the copies. Many symmetry puzzles call for the complex to have its own hydrophobic core. This is a tricky requirement, since the hydrophobic residues that go into the the complex's core must be on the surface of the monomer. The exposed residues lead to a worse "hiding" score for the monomer. To get around the hiding issue, symmetry puzzles often include a filter which awards a bonus for creating a complex with a hydrophobic core. (And, there's usually a penalty for missing the goal.)

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