USS Henshaw (DD-278) was a Clemson-class destroyer in the United States Navy following World War I. She was named for Secretary of the Navy David Henshaw. Built by the Bethlehem Shipbuilding Corporation of Squantum, Massachusetts, Henshaw was launched 28 June 1919, with Miss Ethel H. Dempsey as sponsor. She commissioned at Boston, Massachusetts on 10 December 1919, Lieutenant Commander Martin J. Peterson in command.