Sasaki Isaburo (佐々木異三郎, Sasaki Isaburo) was the commander of the Mimawarigumi, an elite police force from Kyoto. He was the main antagonist of the Baragaki Arc Although he appeared to hate the Shinsengumi, he actually maintained its existence when it was established in exchange of his family's life as a punishment from the Tendoshu. After his family's death under Mukuro's hand, Sasaki had her as his assistant and served the Tendoshuu and the Hitotsubashi Faction while planning to ignite a revolution against the corrupted Bakufu and Tendoshu to restore Edo.