The series focuses on Spider-Man and his alter ego Peter Parker during his college years at Empire State University. As the story begins, Peter has already gained his superpowers and is a part-time freelance photographer for the Daily Bugle. The show features most of Spider-Man's classic villains, including the Kingpin, the Green Goblin, the Lizard, the Scorpion, Doctor Octopus, Mysterio, Shocker, the Rhino, the Vulture, the Chameleon, and Venom. Over the course of the series the single Peter contends with the romantic love interests of Mary Jane Watson, Felicia Hardy and her alter ego, the Black Cat. The show also features appearances from various other Marvel superheroes including the X-Men, the Fantastic Four, Iron Man, Daredevil, Blade, Doctor Strange, the Punisher, and Captain America