The 2010 Beef 'O' Brady's Bowl St. Petersburg was the third edition of the college football bowl game formerly known as the St. Petersburg Bowl. It was played at Tropicana Field in St. Petersburg, Florida, on Tuesday, December 21, 2010 at 8 p.m. (ET). The game was telecast on ESPN and featured the Southern Miss Golden Eagles from Conference USA versus the Louisville Cardinals from the Big East Conference. Louisville was a member of Conference USA from 1996 through 2004.