About: dbkwik:resource/dp0EROa3-AsknhTMbghhQA==

Property	Value
rdfs:label	Mefenamic acid
rdfs:comment	Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. It is typically prescribed for oral administration. Mefenamic acid decreases inflammation (swelling) and uterine contractions by a still unknown mechanism. However it is thought to be related to the inhibition of prostaglandin synthesis.
owl:sameAs	dbr:Mefenamic_acid
dcterms:subject	Medsin dbkwik:resource/HpuNRbF6kreomNTwJMIXKg== dbkwik:resource/xnVWJhmD-CaNU4uoNGemKw==
dbkwik:babyish/property/wikiPageUsesTemplate	dbkwik:resource/6-0UkGdbqzNnnadrHtSJ7A== dbkwik:resource/PuU1I_acjSW6iwml7gbOPw== dbkwik:resource/f6yLdd_EQQSqYQDKN1qCQw== dbkwik:resource/YygQKMV58gLDuV7kdsIwlw== dbkwik:resource/hhuyrtkyhS55apMBhaC97g== dbkwik:resource/3XlL0KrTbwLYmsEvfdDmzQ== dbkwik:resource/nXUmgGV5rL97mxXpUQVqWQ== dbkwik:resource/SWo1WFLMqTRqjmr07Pa2UQ== dbkwik:resource/O6WRbg6032BIswPc688-EQ== dbkwik:resource/0TXoo0F7OGzHLf9imMyr_A==
accessdate	2005-09-28
bioavailability	90.0
verifiedrevid	263877360
metabolism	Hepatic 肝臟
excretion	dbkwik:resource/V-vgoIqp1fa1QLdWkrQkXw== Renal and fecal
ATC prefix	M01
Legal Status	℞-only , POM in UK
N	1
molecular weight	241.285000
protein bound	90.0
Language	en
IUPAC name	2
PubChem	4044
CAS number	61
H	15
pregnancy category	C
ChemSpiderID	3904
ATC suffix	AG01
elimination half-life	2 7200.0
url	http://cardiology.jwatch.org/cgi/content/full/2002/315/3|title=NSAIDs May Increase Risk for Worsening Heart Failure http://archinte.ama-assn.org/cgi/content/abstract/160/6/777|title=Consumption of NSAIDs and the Development of Congestive Heart Failure in Elderly Patients http://www.rxlist.com/cgi/generic3/mefenamic_cp.htm|title=Ponstel Pharmacology, Pharmacokinetics, Studies, Metabolism - Mefenamic Acid - RxList Monographs http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a681028.html|title=MedlinePlus Drug Information: Mefenamic Acid
Watchedfields	changed
DrugBank	APRD0073
routes of administration	Oral 口服
O	2
C	15
abstract	Mefenamic acid is a non-steroidal anti-inflammatory drug used to treat pain, including menstrual pain. It is typically prescribed for oral administration. Mefenamic acid decreases inflammation (swelling) and uterine contractions by a still unknown mechanism. However it is thought to be related to the inhibition of prostaglandin synthesis. Since hepatic metabolism plays a significant role in mefenamic acid elimination, patients with known liver deficiency may be prescribed lower doses. Kidney deficiency may also cause accumulation of the drug and its metabolites in the excretory system. Therefore patients suffering from renal conditions should not be prescribed mefenamic acid.